Brad Pitt and Angelina Jolie headed to Comic-Con?

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Hey, fanboys and girls -- could you handle power couple Brad Pitt and Angelina Jolie invading your turf at Comic-Con 2010?

On July 22, the first day of programming for the annual comic book convention in San Diego, presentations will be made for upcoming movies that feature the actors.

A panel on Pitt’s animated flick ‘Megamind’ will be held starting at 10 a.m. that day in the San Diego Convention Center’s famous Hall H, with attendance from cast members Will Ferrell and Tina Fey promised already.

Then at 1 p.m., Sony Pictures will offer a look at ‘Salt,’ which opens July 23 -- and the Comic-Con schedule is teasing that ‘some very special guests’ will drop in.

Could this mean Pitt and Jolie will roam among the ‘Star Wars’ impersonators and ‘Captain America’ fans? Such an appearance certainly couldn’t hurt as a last-minute call to the box office for ‘Salt’ and to get the buzz ball rolling for the Nov. 5 release of ‘Megamind.’

A Paramount rep can’t confirm Pitt’s attendance ‘at this time,’ and a ‘Salt’-related call to Sony was not immediately returned -- so feel free to draw your own conclusions, and voice them in comments below.

-- Matt Donnelly

The Ministry has amazing Comic-Con coverage planned, so stay tuned. Meanwhile, get the latest on Brangelina right now.