Panel rejects psychedelic drug MDMA as a PTSD treatment in setback for advocates
Federal health advisers voted Tuesday against a first-of-a-kind proposal to use the mind-altering drug MDMA as a treatment for PTSD, handing a setback to psychedelic advocates who hope to win a landmark federal approval and bring the banned drugs into the medical mainstream.
The panel of advisers to the Food and Drug Administration sided 10-1 against the overall benefits of MDMA when used to treat post-traumatic stress disorder. They cited flawed study data, questionable research conduct and significant drug risks, including the potential for heart problems, injury and abuse.
“It seems like there are so many problems with the data — each one alone might be OK, but when you pile them on top of each other … there’s just a lot of questions I would have about how effective the treatment is,” said Melissa Decker Barone, a psychologist with the Department of Veterans Affairs.
The FDA is not required to follow the group’s advice and is expected to make its final decision by August, but the negative opinion could strengthen a rationale for rejecting the treatment.
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The vote followed hours of pointed questions and criticisms about the research submitted on MDMA, also known as ecstasy or molly.
Panelists pointed to flawed studies that could have skewed results, missing follow-up data on patient outcomes and a lack of diversity among participants. The vast majority of patients studied were white; only five Black patients received MDMA, raising questions about the generalizability of the results.
“The fact that this study has so many white participants is problematic, because I don’t want something to roll out that only helps this one group,” said Elizabeth Joniak-Grant, the group’s patient representative.
The FDA advisers also drew attention to allegations of misconduct in the trials that recently surfaced in news stories and a report by the nonprofit Institute for Clinical and Economic Review, which evaluates experimental drug treatments. The incidents include a 2018 report of apparent sexual misconduct by a therapist interacting with a patient.
Lykos Therapeutics, the company behind the study, said it previously reported the incident to the FDA and regulators in Canada, where the therapist is based. Lykos is essentially a corporate spinoff of the nation’s leading psychedelic advocacy group, the Multidisciplinary Assn. for Psychedelic Studies, or MAPS, which funded the studies. The group was founded in 1986 to promote the benefits of MDMA and other mind-altering substances.
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MDMA is the first in a series of psychedelics — including LSD and psilocybin — that are expected to come before the FDA in the next few years. The panel’s negative ruling could derail financial investments in the fledgling industry, which has been funded mainly by a small number of wealthy backers.
MDMA’s main effect is to trigger feelings of intimacy, connection and euphoria. When used to enhance talk therapy, the drug appears to help patients process trauma and let go of disturbing thoughts and memories.
But the panel struggled with the reliability of those results, given the difficulties of objectively testing psychedelic drugs.
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Because MDMA causes intense, psychological experiences, almost all patients in two key studies were able to guess whether they had received the drug or a dummy pill. That’s the opposite of the approach generally required for high-quality drug research, in which bias is minimized by “blinding” patients and researchers as to whether they received the drug that is under investigation.
“I’m not convinced at all that this drug is effective based on the data I saw,” said Dr. Rajesh Narendran, a University of Pittsburgh psychiatrist who chaired the panel.
Panelists also noted the difficulty of knowing how much of patients’ improvement came from MDMA versus the extensive therapy, which totaled more than 80 hours for many. Results were further marred by other complicating factors, including a large number of patients who had previously used MDMA or other psychedelics drugs recreationally.
Nearly three dozen public speakers addressed the panel, including veterans who said they had benefited from MDMA therapy, medical professionals who advised against its use and journalists and independent researchers who reiterated the allegations of misconduct in the trials.
