UCI study reveals more options in treating cancer

Scientists have made a discovery that could help them better treat cancer and cholesterol, according to a new UCI study.

Polyketides, organic compounds used in top selling drugs to treat cholesterol problems and cancer, have been a mystery to scientists for years.

But UCI scientists have discovered how polyketides form their ringlike shape, which may allow for easier manipulation and drug creation, according to a study published online in the Proceedings of the National Academy of Sciences.

Scientists found an enzyme, aromatase/cyclase, to be the key to polyketides’ shape.

Polyketide is used to create antibiotics, anti-cancer drugs used in chemotherapy, anti-oxidants, and drugs that lower cholesterol such as Zocor.

Polyketide-based drugs account for more than $35 billion in sales annually.

— Daniel Tedford